Five Drug Screen test

Intended use

The Multi-Drug Strip Test is an immunochromatographic assay for rapid, qualitative detection of drugs and their principal metabolites in urine at specified cut-off concentrations. A combination is composed from any the following drugs:

DRUG CLASS SENSITIVITY

Phencyclidine 25 ng/ml

marijuana 50 ng/ml

COCAINE/BENZOYLECGONINE 300 ng/ml

barbiturates 200 ng/ml

benzodiazepines 300 ng/ml

Methadone 300 ng/ml

Opiates/Morphine 300 ng/ml

Methamphetamine 500 ng/ml

AMPHETAMINE 1000 ng/ml

Note: The test provides only preliminary data, which should be confirmed by other methods such as gas chromatography/mass spectrometry (GC/MS). Clinical considerations and professional judgment should be applied to any drug of abuse test result, particularly when preliminary positive results are indicated.

summary and explanation of the test

The Multi-drug Strip Test is an easy, fast, qualitative, visually read competitive binding immunoassay method for screening without the need of instrumentation. The method employs unique mixture of monoclonal and polyclonal antibodies to selectively identify the drugs of abuse and their metabolites in test samples with a high degree of sensitivity.

Drug abuse remains a growing social and economical concern in many developed and developing countries throughout the world. The above stated drugs are among the most frequently abused illicit drugs, according to the U.S. Substance Abuse and Mental Health Services Administration. Opiates are among a class of heavily abused prescription drugs.

The sensitivity of the Multi-drug Strip Test is set as required for the screening immunoassays of these drugs in the reference guidelines set by the National Institute on Drug Abuse (NIDA) and the U.S. Department of Health and Human Services.

principle of the test

The Multi-drug Strip Test is a competitive binding immunoassay in which drug and drug metabolites in a urine sample compete with immobilized drug conjugate for limited labeled antibody binding sites. By utilizing antibodies that are specific to different drug classes, the test permits independent, simultaneous detection of six drugs from a single sample. The approximate run time is 5 minutes.

In the assay procedure, urine mixes with labeled antibody-dye conjugate and migrates along a porous membrane. When the concentration of a given drug is below the detection limit of the test, unbound antibody-dye conjugate binds to antigen conjugate immobilized on the membrane, producing a rose-pink color band in the appropriate Test Zone for that drug. Conversely, when the drug level is at or above the detection limit, free drug competes with the immobilized antigen conjugate on the membrane by binding to antibody-dye conjugate, forming an antigen- antibody complex, preventing the development of a rose-pink color band.

Regardless of the drug levels in the sample, a rose-pink color band is produced in each Control Zone (marked “C”) by a parallel immunochemical reaction. These bands serve as built-in quality control measures by demonstrating antibody recognition, verifying that the reagents are chemically active.

REAGENTS AND MATERIALS PROVIDED

1. Test Devices. 1. Test Devices. Contains dye-conjugated

antibody and immobilized

antigen in protein matrix with

sodium azide.

Optional

2. Negative Control I.	Contains buffered protein solution with sodium azide.
3. PCP Positive Control.	Contains PCP at 100 ng/ml in a buffered protein solution with sodium-azide.
4. Marijuana Positive Control	Contains THC at 150 ng/ml in a buffered solution with sodium azide.
5. Barbiturates Positive Control	Contains BAR at 1000 ng/ml in a buffered protein solution with sodium azide.
6. Benzodiazepines Positive Control	Contains BZD at 1000 ng/ml in a buffered protein solution with sodium azide.
7. Methadone Positive Control	Contains MAD at 1000 ng/ml in a buffered protein solution with sodium azide.
8. Opiates Positive Control	Contains MOR at 1000 ng/ml in a buffered protein solution with sodium azide.
9. Cocaine Positive Control	Contains BEG at 1000 ng/ml in a buffered protein solution with sodium azide.
10. Methamphetamine Positive Control	Contains MET at 1500 ng/ml in a buffered protein solution with sodium azide.
11. Amphetamine Positive Control	Contains AMP at 3000 ng/ml in a buffered protein solution with sodium azide.

MATERIALS REQUIRED BUT NOT PROVIDEd

1. Clock or timer.

2. Specimen collection containers.

WARNINGS AND PRECAUTIONStc "WARNINGS AND PRECAUTIONS"

1. For in vitro diagnostic and professional use only.

2. Do not use the test device beyond the expiration date.

3. Urine specimens may be infectious; properly handle and dispose of all used reaction devices in a biohazard container.

4. Visually inspect the foil package to insure it is intact. If the package is not intact, the integrity of the device might be compromised.

STORAGE and stabilitytc "STORAGE and stability"

Store test kit below 28°C; do not freeze. Refer to the expiration date for stability.

test procedure

1. Bring a urine sample and a foil test pouch to room temperature (15°-28°C).

2. Do not break the seal of the pouch until ready to begin testing.

3. Remove a Test Device from the foil pouch.

4. Remove the protective cap and place the revealed strips into the urine sample for 10 seconds. Do not allow the urine level to touch the plastic device.

5. Read the results at 5 minutes.

Note: The result must be interpreted at five minutes. Waiting more than five minutes may cause the reading to be inaccurate. To avoid confusion, discard the test device after interpreting the result.

INTERPRETATION OF RESULTS

Positive: A rose-pink band is visible in each control zone. No color band appearing in the appropriate test zone indicates a positive result for the corresponding drug of that specific test zone.

Negative: A rose-pink band is visible in each control zone and the appropriate test zone, indicating that the concentration of the corresponding drug of that specific test zone is below the detection limit of the test.

Invalid: If a color band is not visible in each of the control zones, the test is invalid. Another test should be run to re-evaluate the specimen.

Note: There is no meaning attributed to line color intensity or width.

Quality control

An internal procedure control has been incorporated into the test to ensure proper kit performance and reliability.

The use of an external control is recommended to verify proper kit performance. Quality control samples should be tested according to quality control requirements established by the testing laboratory.

Limitations of the test

1. This product is designed to be used for the detection of drugs of abuse and their metabolites in human urine only.

2. Although the test is very accurate, there is the possibility false results will occur due to the presence of interfering substances in the specimen sample.

3. The test is a qualitative screening assay and is not suggested for quantitative determination of drug levels in urine, or the level of intoxication.

4. Adulterants such as bleach or other strong oxidizing agents, when added to urine specimens can cause erroneous test results regardless of the analysis method used. If adulteration is suspected, obtain another urine specimen.

Performance characteristics

1. Sensitivity. The Multi-drug Strip Testdetects drugs of abuse and their major metabolites in urine at concentrations equal to or greater than the cut-off level for the specific drug, which is suggested by the National Institute on Drug Abuse (NIDA) for the immunoassay method.

2. Specificity. A study was conducted with the Multi-drug Strip Test to determine the cross-reactivity of drug-related compounds with the test. Substances listed in Table I produced results approximately equivalent to the cutoff levels. A separate study was conducted to determine the cross-reactivity of non-related compounds with the test at concentrations much higher than normally found in the urine of people using or abusing them. No cross reactivity was detected with the substances listed in Table II.

Table I: Concentrations of drug-related compounds showing positive response approximately equivalent to the cut-off set for the test:

The following Opiates-related substances yield a positive result for Opiates:

Morphin 300 ng/ml

Morphine-3-b-D-Glucuronide 300 ng/ml

Codeine 300 ng/ml

Heroin 300 ng/ml

Norcodeine 2,000 ng/ml

Nalorphine 300 ng/ml

Hydrocodone 500 ng/ml

Hydromorphone 300 ng/ml

Oxycodone 1,000 ng/ml

Levorphanol 600 ng/ml

Naloxone 1,000 ng/ml

Thebaine 1,500 ng/ml

Imipramine 50,000 ng/ml

Atropine 100,000 ng/ml

Meperidine 100,000 ng/ml

Ranitidine 100,000 ng/ml

The following Methamphetamine-related substances yield positive results for Methamphetamine:

(+) 3,4-Methylenedioxymethamphetamine (MDMA, Ecstacy) 500 ng/ml

d-Amphetamine 50,000 ng/ml

(+) 3,4-Methylenedioxyamphetamine (MDA) 50,000 ng/ml

(+) Methamphetamine 50,000 ng/ml

D, 1-amphetamine 10,000 ng/ml

Pseudoephedrine 1,000 ng/ml

Ephedrine 25,000 ng/ml

The following Phencyclidine-related substances yield positive results for Phencyclidine:

N-Acetylprocainamide 10,000 ng/ml

Codeine 5,000 ng/ml

p-Hydroxymethamphetamine 50,000 ng/ml

Thebaine 10,000 ng/ml

1-(1-phenylcyclohexyl)-morphine 600 ng/ml

N,N-Diethyl-1-phenyl-Cyclohexylamine 2.0 ng/ml

1-[1-(2-Thienyl)cyclohexyl]-morphine 200 ng/ml

The following Marijuana-related substances yield positive results for Marijuana:

11-Nor-D 8-THC-9-COOH 50 ng/ml

11-Nor-D 9-THC-9-COOH 50 ng/ml

D-8-THC 1 mg/ml

D-9THC 4 mg/ml

Cannabinol 10mg/ml

11-hydroxy-D 9-THC 10mg/ml

The following Amphetamine-related substances yield positive results for Amphetamine:

d-Amphetamine 1000ng/mll

Amphetamine 25,000ng/ml

d,l-Amphetamine 1000 ng/ml

(+)Phenylpropanolamine 50,000 ng/ml

B -Phenylthylamine 90,000 ng/ml

Thyramine 100,000ng/ml

(±) 3,4-Methylenediox 600 ng/ml

Amphetamine (MDA)

Psuedoephedrine 100,000 ng/ml

Ephedrine 250,000 ng/ml

The following Cocaine-related substances yield positive results for Cocaine:

Benzoylecgonine 300 ng/ml

Cocaine 300 ng/ml

Isoxsurpine 1,500 ng/ml

The following Benzodiazepine-related substances yield positive results for Benzodiazepine:

Alphahydroxyaltriazolam 200ng/ml

Alprazolam 62.5 ng/ml

Bromazepam 250 ng/ml

Clobazam 2,500ng/ml

Clorazepate 50 ng/ml

Diazepam 50 ng/ml

Desmethyldiazepam 50 ng/ml

Flunitrazepam 25ng/ml

Flurazepam 100 ng/ml

Lorazepam 250 ng/ml

Lormetazepam 250 ng/ml

Medazepam 1,000 ng/ml

Nitrazepam 250 ng/ml

Nordiazepam 200 ng/ml

Oxazepam 300 ng/ml

Prazepam 100 ng/ml

Temazepam 200 ng/ml

Triazolam 500 ng/ml

The following Barbiturates-related substances yield positive results for Barbiturates:

Secobarbital 200 ng/ml Pentobarbital 200 ng/ml

Amobarbital 200 ng/ml Bromocriptine 200 ng/ml

Barbital 200 ng/ml Clean Jane 260 ng/ml

Butabarbital 200 ng/ml (sodium dodecylsulfate)

Phenobarbital 200 ng/ml Zoloft 200 ng/ml

The following Methadone-related substances yield positive results for Methadone:

Methadone 300ng/ml

Doxylamine 10,000 ng/ml

Laam 10,000 ng/ml

n-methyldiethanolamine 50,000 ng/ml

Pentazocaine 50,000 ng/ml

Tetrahydrozoline 50,000 ng/ml

Dextromethorpham 100,000 ng/ml

Diphenhydromine 100,000 ng/ml

Leuorphanol 100,000 ng/ml

Promethizine 100,000 ng/ml

Table II: Compounds tested and found not to cross-react with the test at a 10mg/ml concentration in urine.

The following compounds do not cross-react with Methamphetamine:

Acetylsalicylic Acid

Amikacin

Amitriptyline

Ampicillan

Arterenol

Aspartame

Atropine Sulfate

Benzoic Acid

Benzoylecgonine HCl

Caffeine

Chlorpheniramine

Chlorpropmazine HCl

Cimetidine

Codeine

Deoxyephedrine

Dextromethorphan

Diazepam

Diethylpropion

Dephenylhydantoin

Doxylamine

Ecgonine HCl

Ecgonine Methyl Ester

Glucose

Histamine

Hydrocodone

Hydromorphone

Indomathacin

Ketoprofen

Levorphanol

D 9-TC

11-nor-D-9-carboxy-THC-9-COOH

Meperdine

Methylphenidate

Methadone

Methaqualone

Morp. Glucuronide

Morphine Sulfate

Oxazepam

Oxycodone

Pendimetrazine

Penicillin G

Pentobarbital

d-Propoxyphene-

Hydrochlorthiazide

Propanol

Phencyclidine

Phenobarbital

Phentermine

Phenylpropanolamine

L-Phenylephrine

Quinine

Ranitidine

Sodium Salicylate

Tryptophan Ecgonine Methyl Ester

Tetracycline

Tetrahydrozoline

Theophylline

Thioridazine\

Triflouperazine

The following compounds do not cross-react with Opiates:

Acetaminophen

Acetylsalicylic Acid

Amikacin

Amitriptyline

Ampicillin

Arterenol

Aspartame

Atropine Sulfate

Benzoic Acid

Benzoylecgonine HCl

Caffeine

Chlorpheniramine

Chlorpropmazine HCl

Cimetidine

Deoxyephedrine

Dextromethorphan

Diazepam

Diethylpropion

Diphenylhydantoin

Doxylamine

Ecgonine HCl

Ecgonine Methyl Ester

Glucose

Histamine

Indomathacin

Ketoprofen

Levorphanol

D - 9 THC

11-nor-D-9-carboxy-THC-9-COOH

Methylphenidate

Methadone

Methaqualone

Morphine Sulfate

Oxazepam

Pendimetrazine

Penicillin G

Pentobarbital

dPropoxyphene-

Hydrochlorothiazide

Propanol

Phencyclidine

Phenobarbital

Phentermine

Phenylpropanolamine

LPhenylephrine

Quinine

Sodium Salicylate

Tryptophan

Tetracycline

Tetrahydrozoline

Theophylline

Thioridazine

Trifluoperazine

The following compounds do not cross-react with Phencyclidine:

Acetaminophen

Acetylsalicyclic Acid

Amikacin

Amitriptyline

Ampicillin

Arterenol

Aspartame

Atropine Sulfate

Benzoic Acid

Benzoylecgonine HCl

Caffeine

Chlorpheniramine

Chlorpropmazine HCl

Cimetidine

Deoxyephedrine

Dextromethorphan

Diazepam

Diethylpropion

Diphenylhydantion

Doxylamine

Ecgonine HC1

Ecgonine Methyl Ester

Glucose

Histamine

Hydrocodone

Hydromorphone

Indomathacin

Ketoprofen

Levorphanol

D -9-THC

11-nor-D -9-carboxy-THC-9 COOH

Meperidine

Methylphenidate

Methadone

Methaqualone

Morp. Glucoronide

Morphine Sulfate

Oxazepam

Oxycodone

Pendimetrazine

Penicillin G

d-Propoxyphene Hydrochlorothiazide

Propanol

Phentermine

Phenylpropanolamine

L-Phenylephrine

Quinine

Ranitidine

Sodium Salicyclate

Tryptophan

Tetracycline

Tetrahydrozoline

Theophylline

Thioridazine

Trifluoperazine

The following compounds do not cross-react with Amphetamine:

Acetaminophen

Acetylsaclicylic Acid

Amikacin

Amitriptyline

Arterenol

Aspartame

Atropine Sulfate

Benzoic Acid

Benzoylecgonine HCl

Caffeine

Chlorpheniramine

Chlorpropmazine HCl

Cimetidine

Codeine

Deoxyephedrine

Dextromethorphan

Diazepam

Diethylpropion

Diphenylhydantoin

Doxylamine

Ecgonine HCl

Ecgonine Methyl Ester

Glucose

Histamine

Hydrocodone

Hydromorphone

Indomathacin

Ketoprofen

Levorphanol

D -9-THC

11-nor-D-9-carboxy-THC-9-COOH

Meperidine

Methylphenidate

Methadone

Methaqalone

Morp. Glucuronide

Morphine Sulfate

Oxazepam

Oxycodone

Pendimetrazine

Penicillin G

Pentobarbital

d-Propoxyphene

Hydrochlorothiazide

Propanol

Phencyclidine

Phenobarbital

Phentermine

Phenylpropanolamine

L-Phenylephrine

Quinine

Ranitidine

Sodium Salicylate

Tryptophan

Tetracycline

Tetrahydrozoline

Theophylline

Thioridazine

Trifluoperazine

The following compounds do not cross-react with Cocaine:

Acetaminophen

Actylsalicylic Acid

Amikacin

Amitriptyline

Ampicillin

Arterenol

Aspartame

Atropine Sulfate

Benzoic Acid

Benzoylecgonine HCl

Caffeine

Chlorpheniramine

Chlorpropmazine HCl

Cimetidine

Codeine

Deoxyephedrine

Dextromethorphan

Diazepam

Hydromorphon

Indomathacin

Ketoprofen

Levorphanol

D -9-THC

Diethylpropion

Dephenylhydantoin

Doxylamine

Ecgonine HCl

Ecgonine Methyl Ester

Glucose

Histamine

Hydrocodone

11-nor-D -9-carboxy-THC-9-COOH

Meperidine

Methylphenidate

Methadone

Methaqualone

Morp. Glucuronide

Morphine Sulfate

Oxazepam

Oxycodone

Pendimetrazine

Penicillin G

Pentobarbital

d-Propoxyphene Hydro-

chlorothiazide

Propanol

Phencyclidine

Phenobarbital

Phentermine

Phenylpropanolamine

L-Phenylephrine

Quinine

Ranitidine

Sodium Salicylate

Tryptophan

Tetrahydrozoline

Theophylline

Thioridazine

Trifluoperazine

The following compounds do not cross-react with Marijuana:

Acetaminophen

4-Acetamidophenol

Acetylsalicyclic acid

Amikacin

Ampicillin

d,l-Amphetamine

Amitriptyline

Arterenol

Aspartame

Atropine sulfate

Benzoic Acid

Benzoylecgonine

Caffeine

Camphor

Chloroquine

Chlorpheniramine

Chlorpromazine HCl

Cocaine Hydrochloride

Cocaine

Cimetidine

Cortisone

Deoxyepinophrine

Dextromethorphan

Diazepam

Digitoxin

Digoxin

Ecgonine Hydrochloride

Ecgonine Methyl Ester

Ephedrine

Epinephrine

Gentisic acid

Glucose

Guaiacol

Histamine

Hydrochlorothiazide

Hydrocodone

Hydromorphone

Homatropine

Imipramine

Isoproterenol

Ketamine

Lidocaine

d-Methamphetamine

Meperidine

Methadone

Methaqualone

Methylpehnidate

Morphine glucuronide

Morphine sulfate

Morphine

Naloxone

Neomycin

Niacinamide

Oxazepam

Perphenazine

Penicillin G

Phencyclidine

Phenobarbital

Phenylethylamine-a

Phenylpropanolamine

Promethazine

Pseudophedrine

Rantidine

Salycyclic acid

Secobarbital

Tetracycline

Tetrahydrozoline

Theophylline

Thiridazine

Triflouperazine

Tryptophan

The following compounds do not cross-react with Barbiturates:

Acetaminophen

Acetylsalicyclic Acid

Amikacin

Amitriptyline

Ampicillin

Arterenol

Aspartame

Atropine Sulfate

Benzoic Acid

Benzoylecgonine HCl

Caffeine

Chlorpheniramine

Chlorpropmazine HCl

Cimetidine

Codeine

Deoxyephedrine

Dextromethorphan

Diazepam

Diethylpropion

Diphenylhydantoin

Doxylamine

Ecgonine HCl

Ecgonine Methyl Ester

Glucose

Histamine

Hydrocodone

Hydromorphone

Indomathacin

Ketoprofen

Levorphanol

D-9-THC

11-nor-D-9-carboxy-THC-9-COOH

Meperidine

Methylphenidate

Methadone

Methaqualone

Morp. Glucuronide

Morphine Sulfate

Oxazepam

Oxycodone

Pendimetrazine

Penicillin G

d-Propoxyphene Hydrochlorothiazide

Propanol

Phencyclidine

Phentermine

Phenylpropanolamine

L-Phenylephrine

Quinine

Ranitidine

Sodium Salicylate

Tryptophan

Tetracycline

Tetrahydrozoline

Theophylline

Thioridazine

Trifluoperazine

The following compounds do not cross-react with Benzodiazepines:

Acetaminophen

Acetylsalicyclic Acid

Amikacin

Amitriptyline

Ampicillin

Arterenol

Aspartame

Atropine Sulfate

Benzoic Acid

Benzoylecgonine HCl

Caffeine

Chlorpheniramine

Chlorpropmazine HCl

Cimetidine

Codeine

Deoxyephedrine

Dextromethorphan

Diethylpropion

Diphenylhydantoin

Diazepam

Doxylamine

Ecgonine HC1

Ecgonine Methyl Ester

Glucose

Histamine

Hydrocodone

Hydromorphone

Indomathacin

Ketoprofen

Levorphanol

D-9-THC

11-nor-D-9-carboxy-THC-9-COOH

Meperidine

Methylphenidate

Methadone

Methaqualone

Morp. Glucoronide

Morphine Sulfate

Oxycodone

Pendimetrazine

Penicillin G

Pentobarbital

d-Propoxyphene Hydrochlorothiazide

Propanol

Phencyclidine

Phenobarbital

Phentermine

Phenylpropanolamine

L-Phenylephrine

Quinine

Ranitidine

Sodium Salicyclate

Tryptophan

Tetracycline

Tetrahydrozoline

Theophylline

Thioridazine

Trifluoperazine

The following compounds do not cross-react with Methadone:

4-Acetamidophenol

Acetophenetidin

N-Acetylprocainamide

Acetylsalicylicacid

Alphenol

Alprazolam

Amitryptyline

Amobarbital

Amoxicillin

l-Amphetamine

d,l-Amphetamine

Ampicillin

Apomorphine

Aprobarbital

ASP-PHEMethylEster

Atropine

BarbitalAcid

BenzoicAcid

Benzoylecgonine

Benzphetamine

Bromazepam

Butabarbital

Butalbital

Cannabidiol

Clonazepam

ChloralHydrate

Chlorazepate

Chlordiazepoxide

Chlorothiazide

Chlorpromazine

Chloroquine

Cholesterol

Clobazem

Clomipramine

Clonazepan

Clonidine

Cocaine

Codeine

Cortisone

(-)Cotinine

Creatinine

Desmethyldiazepam

Deoxycorticosterone

Diazepam

Diclofenac

Diflunisal

Digoxin

4-(Dimethylamino)antipyrine

DLGlutethinide

Doxepin

(+)Ephedrine

(±)Ephedrine

(-)y-Ephedrine

(-)Ephedrine

Erythromycin

b-Estradiol

Estrone-3-sulfate

Ethyl-p-Aminobenzoate

Flunitrazepam

Flurazepam

Furosemide

Gentisicacid

GuaiacolGlyceryl

EsterCarbonate

Glucuronicacid

5-Hydroxytryptamine

Hyppuricacid

Hydralazine

Hydrochlorothiazide

Hydrocodone

Hydrocotisone

O-Hydromorphone

Hydroxyhippuricacid

pHydroxymethamphetamine

3-Hydroxytyramine

Ibuprofen

Imipromine

(-)Isoproterenol

Iproniazid

Isoxsuprine

Ketamine

Ketoprofen

Labetalol

Lidocaine

Loperamide

Lorazepam

Lormetazepam

Maprotiline

Medazepam

Meperidine

Meprobamate

Methaqualone

s)6-Methoxy-a-Methyl-2-

Naphthaleneaceticacid

Methylphenidate

Methyprylon

Morphine-3-b-D-glucuronide

(±)3,4-Methylenedioxy

Methamphetamine

(±)3,4-Methylenedioxy

Amphetamine

Methoxyphenamine

Nalidixicacid

Nalorphine

Naloxone

Naltrexone

Niacinamide

Nifedipine

Nitrazepam

Norcodeine

Norethindrone

d-Norpropoxyphene

Noscapine

Nylidrin

d,l-Octopamine

Oxalicacid

Tetrahydrocortisone

Thebaine

Thiamine

(+)Thiopental

Thioridazine

d,1-Thyroxine

Tolbutamide

Triamterene

Triazolam

Trifluoperazine

Trimethoprim

Trimipramine

Tryptamine

d,1-Tryptophan

Tyramine

d,1-Tyrosine

Uricacid

Verapamil

Zomepirac

AcetylsalicylicAcid

Amikacin

Amitriptyline

Ampicillan

Arterenol

Aspartame

AtropineSulfate

BenzoicAcid

BenzoylecgonineHCl

Caffeine

Chlorpheniramine

ChlorpropmazineHCl

Cimetidine

Codeine

Deoxyephedrine

Dextromethorphan

Diazepam

Diethylpropion

Dephenylhydantoin

Doxylamine

EcgonineHCl

EcgonineMethylEster

Glucose

Histamine

Hydrocodone

Hydromorphone

Indomathacin

Ketoprofen

Levorphanol

D9-TC

11-nor-D-9-carboxy-THC-9-COOH

Meperdine

Methylphenidate

Methadone

Methaqualone

Morp.Glucuronide

MorphineSulfate

Oxazepam

Oxycodone

Pendimetrazine

PenicillinG

Pentobarbital

d-Propoxyphene-

Hydrochlorthiazide

Propanol

Phencyclidine

Phenobarbital

Phentermine

Phenylpropanolamine

L-Phenylephrine

Quinine

Ranitidine

SodiumSalicylate

TryptophanEcgonineMethylEster

Tetracycline

Tetrahydrozoline

Theophylline

Thioridazine\

Triflouperazine

3. Accuracy: The accuracy of the Multi-drug Multi-drug Strip Testwas first tested in urine samples in-house and subsequently in a clinical trial of urine samples submitted to a NIDA certified laboratory. In both cases the laboratories used EMIT II as their screening procedure. All positive samples by either screening method were confirmed by GC/MS. The data was combined and the results are summarized as follows:

3.1 Phencyclidine (PCP)